Dell Precision M4500 memiliki spesifikasi seperti Prosesor Intel Core i7 Quad Core & Extreme Edition atau Intel Core i5 & i7 Dual Core Processor, Layar 15.6? HD UltraSharp LED Display (resolusi 1366×768 pixel), Kartu Grafis NVIDIA Quadro FX 880M Graphics with 1GB5 dedicated memory atau NVIDIA Quadro FX 1800M Graphics with 1GB5 dedicated memory, HDD sampai 500GB 7200RPM, dan memori DDR3 1066MHz/1333MHz maksimal 8GB. Selain itu Dell Precision M4500 dilengkapi juga Webcam 3MP, DVD-ROM, DVD+/-RW atau Blu Ray Drive, Bluetooth 2.1 dan Wifi 802.11 a/g/n, Card Reader 8-in-1, 4 buah port USB 2.0, 1 x eSATA, 1 x DisplayPort, 1 x VGA, 1 x IEEE 1394, 1 x LAN, 1 x Modem, 1 x ExpressCard, 1 x Docking Connector dan sistem operasi Genuine Windows 7 Professional 32/64-Bit.